产品货号：
Z22399
中文名称：
Neuropilin-2/NRP2抗体
英文名称：
Anti-Neuropilin-2/NRP2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Neuropilin-2/NRP2 Antibody |
| 指标别名 | neuropilin 2;1110048P06Rik;N;Np;Np-2;Np2;Npn-2;Npn2;NRP2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | NRP2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human NRP2(45-60aa YPQDYPSHQNCEWIVY),identical to the related mouse sequence and different from the related rat sequence by one amino acid. |
| 实际分子量 | 105KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | NRP2(Neuropilin-2),also called Npn2 or VEGF165R2,encodes a member of the neuropilin family of receptor proteins.The soluble NRP2 was secreted as a 62.5-kD protein following transfection in Chinese hamster ovary cells.The NRP2 gene is mapped on 2q33.3.The NRP2 gene contains 17 exons and spans about 112kb.Sema3b can act to repulse axons expressing neuropilin-2 and can antagonize the repulsive action of Sema3a on axonal growth cones expressing neuropilin-1.This protein may play a role in cardiovascular development,axon guidance,and tumorigenesis.Mice with null mutations in genes encoding Sema3F,and its holoreceptor components Npn2 and plexin A3(PLEXA3),exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size,and also aberrant spine distribution.Moreover,Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro,and in Npn2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency.These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of Npn2 to apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons. |
| Uniprot ID | O60462 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | neuropilin 2 |
| 蛋白名全称 | Neuropilin-2 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：Neuropilin-2/NRP2抗体，Neuropilin-2抗体，NRP2多抗，Anti-Neuropilin-2/NRP2 Antibody